Castleman's disease with autoimmune haemolytic anaemia, subfertility and meningomyelocele.

Castleman's disease (CD) (angiofollicular lymph node hyperplasia) was first described in 1936 (1). It is a rare disease of unknown aetiology affecting the lymph nodes. CD consists of two basic histological types: hyaline-vascular (HV) and plasma-cell (PC), and a mixed type called hyaline-vascular plasma cell type (HV-CV) (2). Clinically, it presents as an indolent disease confined to a single site (unicentric) or less commonly as a more generalised lymphadenopathy (multicentric), accompanied by constitutional symptoms, acute phase response, organomegaly and potential for malignancy. Anaemia is common but usually mild to moderate, normochromic and normocytic (3). Bone marrow cellularity and the myeloid/erythroid ratio (M/E) are normal (3).